Objective: Today, leading companies are trying to increase their profitability in the best possible way by paying attention to factors that are important to customers. This point is the most key basis for their success based on marketing. However, knowledge-based companies are always facing important challenges in the field of marketing management The aim of this research was to analyze the pathology of marketing management of knowledge-based companies in the open innovation approach.

Method: The research was conducted in a mixed (qualitative-quantitative) manner. In the qualitative part, content analysis was used, and in the quantitative part, the Delphi technique was used. The validity and reliability of the data were confirmed using the relative content coefficient and the double coding method.

Findings: The results of the qualitative analysis led to the identification of 30 indicators in the form of 7 dimensions of controlling the turbulence of the new market, ambiguity and information limitations, creating and developing an effective communication network and alliance, effective marketing research, awareness-raising advertising, quality of advertising innovation, flexibility, adaptation and application. The results of the Delphi section showed that the identified indicators and dimensions have appropriate validity.

Conclusion: According to the results obtained, it can be concluded that the most important challenges facing knowledge-based companies in the field of marketing management are the identified dimensions that should be considered by the managers of such companies.